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New clinical trial results for Rhapsido treatment

News from Novartis Pavillon

Novartis has announced promising results from the phase 3 RemIND trial, showing the potential of Rhapsido (remibrutinib) as a targeted therapy for chronic inducible urticaria (CIndU). The study demonstrated that the treatment provides significant symptom relief for patients, offering a new potential option for those whose condition remains inadequately controlled by standard antihistamines.

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Laboratory equipment representing medical research at the Novartis Pavillon.

Novartis Pavillon and Global Health Research: RemIND Data for Rhapsido® at EAACI

Scientific research and healthcare innovation continue to shape modern medicine, a theme deeply explored at the Novartis Pavillon through its immersive Wonders of Medicine exhibition. Groundbreaking developments in immunology further highlight how ongoing clinical investigations address major medical challenges worldwide. Recent findings presented at the European Academy of Allergy and Clinical Immunology (EAACI) Congress demonstrate significant progress in targeted therapies for chronic conditions.

Clinical Trial Insights and Patient Impact

Data from the global RemIND trial presented at the EAACI Congress show that Rhapsido® (remibrutinib) met its primary endpoints across the three most common subtypes of chronic inducible urticaria (CIndU). As a condition affecting an estimated 29 million people globally, CIndU often leaves many individuals dealing with significant symptom burdens despite traditional treatments like H1-antihistamines. The trial results indicate that Rhapsido demonstrated statistically significant and clinically meaningful symptom control compared to placebo, offering a favorable safety profile.

The three primary CIndU subtypes evaluated in the trial include symptomatic dermographism, cold urticaria, and cholinergic urticaria. By targeting the BTK pathway involved in histamine release, the therapy aims to provide sustained relief where approved targeted options have previously been unavailable. Regulatory submissions, including a supplemental New Drug Application to the U.S. Food and Drug Administration for the symptomatic dermographism subtype, point toward broader global health authority reviews throughout 2026.

Exploring Science and Healthcare in Basel

Visitors interested in the intersection of cutting-edge pharmacology, drug development, and future healthcare solutions can explore these topics further through public installations on the Rhine. To discover more cultural spots, exhibitions, and scientific displays across the city, browse the map view, check out the museums list, or plan your visit with Musemap (musemap.art).

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What is the RemIND trial?

The RemIND trial is a global phase 3 clinical study evaluating the efficacy and safety of Rhapsido (remibrutinib) in adult patients with chronic inducible urticaria (CIndU) who are not adequately controlled by H1-antihistamines.

What are the common subtypes of chronic inducible urticaria?

The study focused on the three most common subtypes: symptomatic dermographism, cold urticaria, and cholinergic urticaria.

What did the recent clinical trial results show?

The results indicated that Rhapsido met its primary endpoints across the three most common CIndU subtypes, showing statistically significant and clinically meaningful symptom control compared to a placebo.

Is Rhapsido currently an approved treatment?

Rhapsido is currently approved in several countries, including the U.S. and the EU, for the treatment of chronic spontaneous urticaria (CSU) in specific patient groups. Novartis has submitted applications to expand its use to specific CIndU subtypes.

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